Animal models - Physiology

To assess the role of tissue microbiota in metabolic diseases, Vaiomer uses nutritional animal models of metabolic diseases together with clinical samples from human. These animal models of type 2 diabetes, obesity and related disorders are housed in a modern SOPF animal facility (according to the Federation of European Laboratory Animal Science Association).

Example of mouse models of metabolic disorders used at Vaiomer:

  • Nutritional models: High Fat Diet mouse (acute or chronic diets)
  • Genetic models: ob/ob; db/db, conditional knock-out (Cre/Lox).

Physiological studies and metabolic phenotyping, in particular in relation to glucose and lipid metabolism, are routinely performed with:

  • Body weight and weight gain
  • Oral or ip glucose tolerance test,
  • Oral or ip insulin tolerance test,
  • Glycaemia, insulin and leptin concentrations (ELISA)

In addition to metabolic and physiological phenotyping, Vaiomer has a strong expertise in tissue and organ harvesting and preparation, in particular in relation to the high standard required for tissue microbiota analysis and high-scale omics technology. Analyzed tissues range from classical body fluid samples (blood, stools …) to more challenging tissues requiring our in-house specific expertise (intestinal mucosa separation, adipose tissues with specific fat pads dissection, brain, liver …).

Vaiomer forged a partnership with the company Physiogenex to provide an extended integrated service to nutrition and pharma industries. Physiogenex is a leading contract research organization providing validated nutritional animal models to evaluate diabetes, obesity, liver diseases (NASH), dyslipidemia, atherosclerosis and cardiovascular complications in rodents.

 

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