Resources
Probiotic strains translocate to the tumor and improve ICI efficacy through indole-3-aldehyde release
In recent years, several studies have shown the importance of both the gut and the tumor microbiome in cancer progression and immune checkpoint inhibitors (ICI) response. Thus, microbiomes appear as a new source of therapeutic strategies to expand the efficacy and...
The human tumor microenvironment is colonized by cancer type–specific bacteria and fungi
Several studies have shown the importance of the gut microbiota in cancer progression and treatment response. Although bacteria were first detected in human tumors more than 100 years ago, the tumor microbiome has been overlooked, mainly because its characterization...
Microbiomes modulate the local immune response, influencing immunotherapy response and toxicity
Immunotherapy has revolutionized the treatment of several cancers. However, it remains elusive why only some patients benefit from these treatments and why some patients experience immune-related adverse events (irAEs). Microbiomes are under investigation to...
Resistance to anti-PD-1 immunotherapy can be attributed to the gut microbiome
Immunotherapies (Immune Checkpoint Inhibitors, ICI) have become a powerful therapeutic strategy for treating a variety of cancers. It is a very exciting area but with challenges. Indeed, the patient response to these therapies is often heterogeneous and not durable,...
Gut microbiota dysbiosis contributes to the tumorigenic process, even in extra-intestinal malignancies
Numerous metagenomics-based studies have associated gut microbiota dysbiosis with the progression and resistance to immunotherapy of intestinal and non-intestinal cancers. It remains unclear whether the dysbiosis is causing the tumorigenic process or the consequence...
Metabolism and obesity: influence of prebiotics, probiotics and symbiotics on microbiomes and liver health
Prebiotic, probiotic and symbiotic treatments affect intestinal and adipose tissue microbiomes, as well as gut and liver metabolitesThis article by Yde et al., explored the changes in the microbiota composition and metabolite levels induced by pre- and/or probiotic in...
Metabolism and Major Depression: Blood microbiome and metabolome exploration
Response to antidepressant is associated with blood microbiome and metabolome of patients with major depressive episodes (MDE)In this article, Ciocan and colleagues explored the blood microbiome and metabolome in patients with major depressive episodes (MDE) before...
Metabolism and Obesity: the liver microbiome & the development of NAFLD
Changes in the liver microbiome as a risk factor for the development of NAFLD in obese individualsIn this paper, Suppli et al., study the microbiome in liver biopsies and blood from healthy lean and obese patients: → Liver microbiome profiling separated obese...
Metabolism and Obesity: Oral microbiota and fat taste sensitivity
The relationship between oral microbiome and fat taste sensitivity in obese patients after sleeve gastrectomyBernard et al. explored the relationship between oral microbiota composition & fat taste sensitivity in obese patients after Vertical Sleeve Gastrectomy. →...
Metabolism and T2D: GLP-1 sensitivity is linked with clock genes and ileal microbiome
Association between the gut-brain-beta cell glucagon-like peptide-1(GLP-1)-dependent axis, the gut microbiota and the insulin sensitivityGrasset et al. explored the association between the gut-brain-beta cell glucagon-like peptide-1 (GLP-1)-dependent axis, the gut...